PRINCIPAL SCIENTIST, NUCLEIC ACID MOLECULAR BIOLOGY

Generation Bio is a biotechnology company changing what is possible for people living with T cell-driven autoimmune diseases. The company is developing novel therapeutics leveraging its T cell selective cell-targeted lipid nanoparticle (ctLNP) to deliver siRNA in vivo, enabling modulation of T cell activity that causes inflammation and auto-reactive tissue destruction. By selectively modulating T cells that drive disease pathology, ctLNP-siRNA therapeutics could potently block target function with sequence-level specificity while sparing the broader immune system. This potent new modality is designed to reach targets that are poorly drugged by other approaches, opening a broad indication space of T cell driven autoimmune diseases.

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SUMMARY :

Generation Bio is seeking an energetic and motivated Principal Scientist with experience and technical expertise building siRNA-based therapies. The successful candidate will lead design approaches for optimizing siRNA cargo, through both molecular and chemical intervention. As part of this effort, the Principal Scientist will help build the core infrastructure required for iterative design and evaluation of siRNA molecules to drive program and platform development. The position is cross-functional, requiring collaboration with delivery and preclinical teams to develop siRNA cargo that satisfies program needs. The Principal Scientist will conceive and implement novel approaches to address key platform development goals, developing and driving execution of technical plans individually and as part of teams. This position reports to the VP, head of Molecular Biology and will be responsible for building functional expertise and leading cross functional teams.

RESPONSIBILITIES :

• Lead design approaches for optimizing siRNA therapeutic molecules for high potency, selectivity and durability
• Build the core infrastructure required for iterative design and evaluation of siRNA molecules to drive program and platform development
• Collaborate with pre-clinical teams to develop therapeutic molecules based on program needs.
• Lead execution of research individually and as part of function and cross functional teams.
• Present scientific ideas and results effectively to different teams and groups within the organization.
• Accountable for on-time execution of experimental projects to advance our platform.

QUALIFICATIONS :

POSITION : Full-Time, Exempt

EEOC Statement : Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race (to include traits historically associated with race including, but not limited to, hair texture, hair type, hair length, and protective hairstyles such as braids, locks, twists, hair coverings, and Bantu knots), color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.